Awards / Tanabe Award
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Date Enacted: June 10, 1994 Date Last Amended: February 5, 2015 |
Rules
| 1. Institution： | The Japanese Society of Toxicology (“Society”) hereby institutes the Japanese Society of Toxicology Tanabe Award (“Award”). |
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| 2. Eligibility： | The purpose of JSOT shall be to promote the progress/development of research in the field of toxicology through the following activities: | |
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| 3. Awarding： | The Award comprising a testimonial and extra prize shall be presented to the winner(s) at the annual meeting of the Society. In principle, the Award shall be granted to up to four research papers for the year; however, if none are judged satisfactory, no award will be given. | |
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| 4. Selection： |
（1）The Selection Sub-Committee of Japanese Society of Toxicology Tanabe Award (“Selection Sub-Committee”) is established under the Editorial Committee for selecting the winner(s). （2）The President shall confer with the Chairperson for designating the Selection Sub-Committee Chairperson. The Chairperson of Editorial Committee shall confer with the Selection Sub-Committee Chairperson for designating the Selection Sub-Committee members. The designated members shall hold office for one year, and may be re-designated. （3）If a Selection Sub-Committee member belongs to the same chair (or the corresponding department of an entity other than a university) as the Award nominee(s), he/she shall not chair the Selection Sub-Committee. （4）The research papers eligible for the Award shall be those which were originally published in the bulletin regularly issued by the Society in the previous year. （5）The secretariat of the Society shall deliver the list of eligible research papers published in the previous year to the Selection Sub-Committee members each year. （6）The Selection Sub-Committee shall select the Award winner(s), and the Sub-Committee Chairperson shall report the results, including a case in which no winners are selected, to the President and the Chairperson of Editorial Committee. |
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Winners
30th 2024
| Paper： | Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pharmaceutical and food-related compounds |
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| Author： |
Takashi Kitaguchi, Shinichiro Horiuchi, Yukie Kuroda, Katsutoshi Ohno, Kazuhiro Kobayashi, Mitsuru Tanaka, Seiichi Ishida J. Toxicol. Sci., Vol. 48, No. 5, 251-261, 2023 |
| Paper： | Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study |
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| Author： |
Masao Togao, Takashi Kurakawa, Shinnosuke Tajima, Gaku Wagai, Yuki Ohta-Takada, Jun Otsuka, Akinobu Kurita, Koji Kawakami J. Toxicol. Sci., Vol. 48, No. 6, 333-343, 2023 |
| Paper： | Preclinical in vitro evaluation of immune suppression induced by GYM329, Fc-engineered sweeping antibody |
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| Author： |
Yoshika Iwata, Hitoshi Katada, Momoko Okuda, Yoshiaki Doi, Tim Jang Ching, Asako Harada, Akira Takeiri, Masaki Honda, Masayuki Mishima J. Toxicol. Sci., Vol. 48, No. 7, 399-409, 2023 |
| Paper： | Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7 |
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| Author： |
Motomu Shimizu, Motoki Hojo, Kiyomi Ikushima, Yukio Yamamoto, Ai Maeno, Yoshimitsu Sakamoto, Naozumi Ishimaru, Yuhji Taquahashi, Jun Kanno, Akihiko Hirose, Jin Suzuki, Akiko Inomata, Dai Nakae J. Toxicol. Sci., Vol. 48, No. 12, 617-639, 2023 |
29th 2023
| Paper： | A physiologically based kinetic modeling of ethyl tert-butyl ether in humans–An illustrative application of quantitative structure-property relationship and Monte Carlo simulation |
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| Author： |
Saori Watanabe-Matsumoto, Kikuo Yoshida, Yuriko Meiseki,Seiichi Ishida, Akihiko Hirose, Takashi Yamada J. Toxicol. Sci. Vol.47, No.2, 77-87, 2022 |
| Paper： | Fetal loss due to Th1-skewed Th1/Th2 balance with increase (not decrease) of regulatory T cells in abortion-prone mouse model |
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| Author： |
Miho Sakakibara, Yosuke Maeda, Kazuichi Nakamura J. Toxicol. Sci. Vol.47, No.8, 327-336, 2022 |
| Paper： | CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis |
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| Author： |
Qiyue Zhang, Shiori Taniguchi, Kanako So, Masahiro Tsuda, Yuriko Higuchi, Mitsuru Hashida, Fumiyoshi Yamashita J. Toxicol. Sci. Vol.47, No.8, 337-348, 2022 |
| Paper： | Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity |
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| Author： |
Tomomi Yoda, Tomoaki Tochitani, Toru Usui, Mami Kouchi, Hiroshi Inada, Takuomi Hosaka, Yuichiro Kanno, Izuru Miyawaki, Kouichi Yoshinari J. Toxicol. Sci. Vol.47, No.9, 359-373, 2022 |
28th 2022
| Paper： | Development of a new in vitro assay system for evaluating the effects of chemicals on DNA methylation |
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| Author： |
Maky Ideta-Otsuka, Misato Miyai, Naoki Yamamoto, Ayaka Tsuchimoto, Hideki Tamura, Kentaro Tanemura, Makoto Shibutani, Katsuhide Igarashi J. Toxicol. Sci. Vol. 46, No. 2, 83-90, 2021 |
| Paper： | Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury |
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| Author： |
Yuki Shimizu, Takamitsu Sasaki, Eri Yonekawa, Hirokazu Yamazaki, Rui Ogura, Michiko Watanabe, Takuomi Hosaka, Ryota Shizu, Jun-ichi Takeshita, Kouichi Yoshinari J. Toxicol. Sci. Vol.46, No. 4, 167-176, 2021 |
| Paper： | Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing |
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| Author： |
Kayoko Tsuji, Shigeru Yamada, Kazuya Hirai, Hiroshi Asakura, Yasunari Kanda J. Toxicol. Sci. Vol. 46, No. 9, 425-435, 2021 |
27th 2021
| Paper： | Adjustment of a no expected sensitization induction level derived from Bayesian network integrated testing strategy for skin sensitization risk assessment |
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| Author： |
Yuki Otsubo, Taku Nishijo, Hideyuki Mizumachi, Kazutoshi Saito, Masaaki Miyazawa, Hitoshi Sakaguchi J. Toxicol. Sci. Vol.45, No.1, 57-67, 2020 |
| Paper： | Integration of read-across and artificial neural network-based QSAR models for predicting systemic toxicity: A case study for valproic acid |
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| Author： |
Tomoka Hisaki, Maki Aiba née Kaneko, Morihiko Hirota, Masato Matsuoka, Hirokazu Kouzuki J. Toxicol. Sci. Vol.45, No.2, 95-108, 2020 |
| Paper： | In silico systems for predicting chemical-induced side effects using known and potential chemical protein interactions, enabling mechanism estimation |
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| Author： |
Yuto Amano, Hiroshi Honda, Ryusuke Sawada, Yuko Nukada, Masayuki Yamane, Naohiro Ikeda, Osamu Morita, Yoshihiro Yamanishi J. Toxicol. Sci. Vol.45, No.3, 137-149, 2020 |
26th 2020
| Paper： | Methylmercury-induced neural degeneration in rat dorsal root ganglion is associated with the accumulation of microglia/macrophages and the proliferation of Schwann cells |
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| Author： |
Yo Shinoda, Shunsuke Ehara, Satoshi Tatsumi, Eiko Yoshida, Tsutomu Takahashi, Komyo Eto, Toshiyuki Kaji, Yasuyuki Fujiwara J. Toxicol. Sci. Vol.44, No.3, 191-199, 2019 |
| Paper： | Applicability of amino acid derivative reactivity assay for prediction of skin sensitization by combining multiple alternative methods to evaluate key events |
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| Author： |
Yusuke Yamamoto, Masaharu Fujita, Sayaka Wanibuchi, Ayako Sato, Miyuki Akimoto, Yasuhiro Katsuoka, Atsushi Ono, Toshihiko Kasahara J. Toxicol. Sci. Vol.44, No.9, 585-600, 2019 |
| Paper： | Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells |
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| Author： |
Tatsuya Ikuno, Shunsuke Ito, Tomoaki Inoue J. Toxicol. Sci. Vol.44, No.11, 789-797, 2019 |
| Paper： | Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling |
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| Author： |
Takehito Isobe, Masaki Honda, Ryuichi Komatsu, Mitsuyasu Tabo J. Toxicol. Sci. Vol.44, No.12, 859-870, 2019 |
25th 2019
| Paper： | Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR |
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| Author： |
Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari J. Toxicol. Sci. Vol.43, No.7, 443-450, 2018 |
| Paper： | Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model |
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| Author： |
Takehito Isobe, Masaki Honda, Ryuichi Komatsu, Mitsuyasu Tabo J. Toxicol. Sci. Vol.43, No.8, 493-506, 2018 |
| Paper： | 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells |
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| Author： |
Shigeru Yamada, Daiju Yamazaki, Yasunari Kanda J. Toxicol. Sci. Vol.43, No.12, 727-734, 2018 |
| Paper： | Comparative assessment of 24-hr primary skin irritation test and human patch test data with in vitro skin irritation tests according to OECD Test Guideline 439 (for quasi-drugs in Japan) |
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| Author： |
Mariko Sugiyama, Masaharu Akita, Nathalie Alépée, Miyuki Fujishiro, Shigenobu Hagino, Yuki Handa, Hidefumi Ikeda, Noriyasu Imai, Setsuko Jitsukawa, Masakazu Katoh, Koji Kurihara, Daiki Kyotani, Shigeyuki Nomura, Yuko Okamoto, Hidenobu Okumura, Takashi Omori, Kenji Sugibayashi, Hiroaki Todo, Akemi Toyoda, Yasuo Ohno J. Toxicol. Sci. Vol.43, No.12, 751-768, 2018 |
24th 2018
| Paper： | Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance |
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| Author： |
Hiroko Izumi-Nakaseko, Yuji Nakamura, Takeshi Wada, Kentaro Ando, Yasunari Kanda, Yuko Sekino and Atsushi Sugiyama J. Toxicol. Sci. Vol.42, No.2, 183-192, 2017 |
| Paper： | Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells |
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| Author： |
Naoya Hirata, Shigeru Yamada, Yuko Sekino and Yasunari Kanda J. Toxicol. Sci. Vol.42, No.2, 193-204, 2017 |
| Paper： | Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics |
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| Author： |
Taisuke Kawamoto, Yuichi Ito, Osamu Morita and Hiroshi Honda J. Toxicol. Sci. Vol.42, No.4, 427-436, 2017 |
23rd 2017
| Paper： | Tributyltin induces G2/M cell cycle arrest via NAD+-dependent isocitrate dehydrogenase in human embryonic carcinoma cells |
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| Author： |
Miki Asanagi, Shigeru Yamada, Naoya Hirata, Hiroshi Itagaki, Yaichiro Kotake, Yuko Sekino and Yasunari Kanda J. Toxicol. Sci. Vol.41, No.2, 207-215, 2016 |
| Paper： | Detection of non-genotoxic hepatocarcinogens and prediction of their mechanism of action in rats using gene marker sets |
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| Author： |
Masayuki Kanki, Min Gi, Masaki Fujioka and Hideki Wanibuchi J. Toxicol. Sci. Vol.41, No.2, 281-292, 2016 |
| Paper： | Demethylation of methylmercury and the enhanced production of formaldehyde in mouse liver |
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| Author： |
Takuya Uchikawa, Toshihiro Kanno, Isao Maruyama, Nobuko Mori, Akira Yasutake, Yuji Ishii and Hideyuki Yamada J. Toxicol. Sci. Vol.41, No.4, 479-487, 2016 |
| Paper： | Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals? |
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| Author： |
Yoshika Iwata, Asako Harada, Toshiko Hara, Chiyomi Kubo, Tomoaki Inoue, Mitsuyasu Tabo, Corinne Ploix, Tobias Manigold, Heather Hinton and Masayuki Mishima J. Toxicol. Sci. Vol.41, No.4, 523-531, 2016 |
22nd 2016
| Paper： | Prenatal diesel exhaust exposure disrupts the DNA methylation profile in the brain of mouse offspring |
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| Author： |
Ken Tachibana, Kohei Takayanagi, Ayame Akimoto, Kouji Ueda, Yusuke Shinkai, Masakazu Umezawa, Ken Takeda J. Toxicol. Sci. Vol.40, No.1, 1-11, 2015 |
| Paper： | In silico risk assessment for skin sensitization using artificial neural network analysis |
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| Author： |
Kyoko Tsujita-Inoue, Tomomi Atobe, Morihiko Hirota, Takao Ashikaga, Hirokazu Kouzuki J. Toxicol. Sci. Vol.40, No.2, 193-209, 2015 |
| Paper： | Disruption of spindle checkpoint function ahead of facilitation of cell proliferation by repeated administration of hepatocarcinogenesis in rats |
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| Author： |
Masayuki Kimura, Sayaka Mizukami, Yousuke Watanabe, Yasuko Hasegawa-Baba, Nobuhiko Onda, Toshinori Yoshida, Makoto Shibutani J. Toxicol. Sci. Vol.40, No.6, 855-871, 2015 |
| Paper： | Covalent binding of quinones activates the Ah receptor in Hepa1c1c7 cells |
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| Author： |
Yumi Abiko, Alvaro Puga, Yoshito Kumagai J. Toxicol. Sci. Vol.40, No.6, 873-886, 2015 |
21st 2015
| Paper： | An RNA synthesis inhibition assay for detecting toxic substances using click chemistry |
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| Author： |
Yukiko Kametani, Shigenori Iwai and Isao Kuraoka J. Toxicol. Sci. Vol.39, No.2, 293-299, 2014 |
| Paper： | Improvement of the evaluation method for teratogenicity using zebrafish embryos |
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| Author： |
Akihito Yamashita, Hiroshi Inada, Kazuhiro Chihara, Toru Yamada, Jiro Deguchi and Hitoshi Funabashi Toxicol. Sci. Vol.39, No.3, 453-464, 2014 |
| Paper： | FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation |
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| Author： |
Ke Du, Tsutomu Takahashi, Shusuke Kuge, Akira Naganuma and Gi-Wook Hwang J. Toxicol. Sci. Vol.39, No.6, 861-866, 2014 |
20th 2014
| Paper： | Simulation of acute reference dose (ARfD) settings for pesticides in Japan |
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| Author： |
Midori Yoshida, Daisetsu Suzuki, Kiyoshi Matsumoto, Mariko Shirota, Kaoru Inoue, Miwa Takahashi, Takeshi Morita and Atsushi Ono J. Toxicol. Sci. Vol.38, No.2, 205-214, 2013 |
| Paper： | A convenient method to assess chemical modification of protein thiols by electrophilic metals |
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| Author： |
Takashi Toyama, Yasuhiro Shinkai, Toshiyuki Kaji and Yoshito Kumagai J. Toxicol. Sci. Vol.38, No.3, 477-484, 2013 |
| Paper： | Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death |
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| Author： |
Keishi Ishida, Yaichiro Kotake, Masatsugu Miyara, Kaori Aoki, Seigo Sanoh, Yasunari Kanda and Shigeru Ohta J. Toxicol. Sci. Vol.38, No.3, 513-521, 2013 |
| Paper： | Mechanisms of cadmium-induced chronotoxicity in mice |
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| Author： |
Nobuhiko Miura, Atsushige Ashimori, Asuka Takeuchi, Katsumi Ohtani, Naoko Takada, Yukie Yanagiba, Masaharu Mita, Masako Togawa and Tatsuya Hasegawa J. Toxicol. Sci. Vol.38, No.6, 947-957, 2013 |
19th 2013
| Paper： | Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence |
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| Author： |
Katsuhide Igarashi, Satoshi Kitajima, Ken-ichi Aisaki, Kentaro Tanemura, Yuhji Taquahashi, Noriko Moriyama, Eriko Ikeno, Nae Matsuda, Bruce Blumberg and Jun Kanno J. Toxicol. Sci., Vol.37, No.2, 373-380, 2012 |
| Paper： | Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice |
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| Author： |
Shingo Arakawa, Takanori Maejima, Kazunori Fujimoto, Ryo Atsumi and Yasushi Yamazoe J. Toxicol. Sci., Vol.37, No.3, 595-605, 2012 |
| Paper： | A method for detecting covalent modification of sensor proteins associated with 1,4-naphthoquinone-induced activation of electrophilic signal transduction pathways |
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| Author： |
Reiko Hirose, Takashi Miura, Ryo Sha, Yasuhiro Shinkai, Toshiko Tanaka-Kagawa and Yoshito Kumagai J. Toxicol. Sci., Vol.37, No.5, 891-898, 2012 |
| Paper： | Aberrant activation of ubiquitin D at G2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats |
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| Author： |
Eriko Taniai, Atsunori Yafune, Hitomi Hayashi, Megu Itahashi, Yukiko Hara-Kudo, Kazuhiko Suzuki, Kunitoshi Mitsumori and Makoto Shibutani J. Toxicol. Sci., Vol.37, No.6, 1093-1111, 2012 |
18th 2012
| Paper： | Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo. |
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Maki Tokumoto, Yasuyuki Fujiwara, Tatsuya Hasegawa and Yoshiyuki Seko J. Toxicol.Sci., Vol. 36, No. 2, 191-200 (2011) |
| Paper： | Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans – toxicological implications |
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| Author： |
Hidetoshi Shindoh, Kohnosuke Nakano and Takemi Yoshida J. Toxicol.Sci., Vol. 36, No.4, 411-422 (2011) |
| Paper： | Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats. |
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| Author： |
Akio Kobayashi, Hideaki Yokoyama, Jiro Kataoka, Tomio Ishida, Hideyuki Kuno, Shoichiro Sugai, and Kayoko Shimoi J. Toxicol.Sci., Vol. 36, No. 3, 325-337 (2011) |
| Paper： | Analysis of altered gene expression specific to embryotoxic chemical treatment during embryonic stem cell differentiation into myocardiac and neural cells. |
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| Author： |
Noriyuki Suzuki, Satoshi Ando, Kayo Sumida and Koichi Saito J. Toxicol.Sci., Vol. 36, No. 5, 569-585 (2011) |
17th 2011
| Paper： | Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity |
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| Author： |
Akiko Honda, Hiroaki Komuro, Tatsuya Hasegawa, Yoshiyuki Seko, Akinori Shimada, Hisamitsu Nagase, Isao Hozumi, Takashi Inuzuka, Hideaki Hara, Yasuyuki Fujiwara and Masahiko Satoh J. Toxicol. Sci., Vol. 35, No.2, 209-215. (2010) |
| Paper： | Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis |
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| Author： |
Yuki Matsumoto, Takumi Ishida, Tomoki Takeda, Takayuki Koga, Misaki Fujii, Yuji Ishii, Yoshinori Fujimura, Daisuke Miura, Hiroyuki Wariishi and Hideyuki Yamada J. Toxicol. Sci., Vol. 35, No.3, 365-373. (2010) |
| Paper： | Improvement of the embryonic stem cell test endpoint analysis by use of field potential detection |
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| Author： |
Naoteru Koseki, Jiro Deguchi, Toru Yamada, Hitoshi Funabashi and Takaki Seki J. Toxicol. Sci., Vol. 35, No.5, 619-629. (2010) |
| Paper： | 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKβ/NF-κB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation |
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| Author： |
Daigo Sumi, Masako Akimori, Ken-ichiro Inoue, Hirohisa Takano and Yoshito Kumagai J. Toxicol. Sci., Vol. 35, No.6, 891-898. (2010) |
16th 2010
| Paper： | Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy |
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| Author： |
Mitsuhiro Hirode, Ko Omura, Naoki Kiyosawa, Takeki Uehara, Toshinobu Shimuzu, Atsushi Ono, Toshikazu Miyagishima, Taku Nagao, Yasuo Ohno and Tetsuro Urushidani J. Toxicol. Sci., Vol. 34, No.3, 281-293. (2009) |
| Paper： | Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats: implication of hormesis-like effects |
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| Author： |
Yasufumi Shutoh, Makio Takeda, Ryoichi Ohtsuka, Atsuko Haishima, Satoru Yamaguchi, Hideaki Fujie, Yutaka Komatsu, Keizo Maita and Takanori Harada J. Toxicol. Sci., Vol. 34, No.5, 469-482. (2009) |
| Paper： | Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1 |
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| Author： |
Daigo Sumi, Yumiko Numasawa, Akiko Endo, Noriko Iwamoto and Yoshito Kumagai J. Toxicol. Sci., Vol. 34, No.6, 627-635. (2009) |
| Paper： | Comprehensive analysis of hepatic gene and protein expression profiles on phenobarbital- or clofibrate-induced hepatic hypertrophy in dogs |
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| Author： |
Toshihiko Makino, Junzo Kinoshita, Shingo Arakawa, Kazumi Ito, Yosuke Ando, Takashi Yamoto, Munehiro Teranishi, Atsushi Sanbuissho and Hiroyuki Nakayama J. Toxicol. Sci., Vol. 34, No.3, 647-661. (2009) |
15th 2009
| Paper： | Role of TNF-α and extracellular ATP in THP-1 cell activation following allergen exposure |
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| Author： |
Masaaki Miyazawa, Yuichi Ito, Nanae Kosaka, Yuko Nukada, Hitoshi Sakaguchi, Hiroyuki Suzuki and Naohiro Nishiyama J. Toxicol. Sci., Vol. 33, No.1, 71-83. (2008) |
| Paper： | Prevention of incipient diabetic cardiomyopathy by high-dose thiamine |
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| Author： |
Yuka Kohda, Hisashi Shirakawa, Kazuhiko Yamane, Kaoru Otsuka, Tatsuji Kono, Fumio Terasaki and Takao Tanaka J. Toxicol. Sci., Vol. 33, No.4, 459-472. (2008) |
| Paper： | Protective role of metallothionein in bone marrow injury caused by X-irradiation |
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| Author： |
Kiyoshi Shibuya, Junko S. Suzuki, Hideaki Kito, Akira Naganuma, Chiharu Tohyama and Masahiko Satoh J. Toxicol. Sci., Vol. 33, No.4, 479-484. (2008) |
| Paper： | Decrease in protein binding and its effect on toxicokinetics (TK) / toxicodynamics (TD) of diclofenac and propranolol in pregnant rats |
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| Author： |
Hiroaki Miida, Yumiko Noritake, Hitomi Shimoda, Kumi Honda, Toshiki Matsuoka, Ken Sakurai, Makoto Shirai, Sunao Manabe, Wataru Takasaki and Koichi Ueno J. Toxicol. Sci., Vol. 33, No.5, 525-536. (2008) |
14th 2008
| Paper： | OPTIMIZATION OF AN ANIMAL TEST PROTOCOL FOR TOXICOGENOMICS STUDIES (II); A CROSS-LABORATORY GENE EXPRESSION ANALYSIS |
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| Author： |
Kayo SUMIDA, Koichi SAITO, Kenji OEDA, Masanori OTSUKA, Kazunari TSUJIMURA, Hideki MIYAURA, Masaru SEKIJIMA, Koji NAKAYAMA, Yukiko KAWANO, Yuki KAWAKAMI, Makoto ASAMOTO and Tomoyuki SHIRAI J.Toxicol.Sci.,Vol.32,No.1,33-45.(2007) |
| Paper： | EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES - EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE |
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| Author： |
Toshinori YAMAMOTO, Kaori TOMIZAWA, Masaaki FUJIKAWA, Yasushi SATO, Hiroshi YAMADA and Ikuo HORII J.Toxicol.Sci.,Vol.32,No.3,205-215.(2007) |
| Paper： | CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE - REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION - |
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| Author： |
Tamio FUKUSHIMA, Yoshimasa HAMADA, Hiroshi YAMADA and Ikuo HORII J.Toxicol.Sci.,Vol.32,No.4,401-409,(2007) |
13th 2007
| Paper： | INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER: TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS |
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| Author： |
Toshinori YAMAMOTO, Rie KIKKAWA, Hiroshi YAMADA and Ikuo HORII J Toxicol Sci 2006; 31:49-60 |
| Paper： | INVOLVEMENT OF RAF-1/MEK/ERK1/2 SIGNALING PATHWAY IN ZINC-INDUCED INJURY IN RAT RENAL CORTICAL SLICES |
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| Author： |
Yuka KOHDA, Yoshiko MATSUNAGA, Ryugo SHIOTA, Tomohiko SATOH, Yuko KISHI, Yoshiko KAWAI and Munekazu GEMBA J Toxicol Sci 2006; 31:207-217 |
12th 2006
| Paper： | ROLES OF μ-OPIOID RECEPTORS IN DEVELOPMENT OF TOLERANCE TO DIISOPROPYLFLUOROPHOSPHATE (DFP) |
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| Author： |
Lu-Tai TIEN, Lir-Wan FAN, Tangeng MA, Horace H. LOH and Ing Kang HO J. Toxicol. Sci.,2005; 30:43-59 |
| Paper： | INHIBITION OF NF-κB ACTIVATION DURING ISCHEMIA REDUCES HEPATIC ISCHEMIA/REPERFUSION INJURY IN RATS |
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| Author： |
Nobuaki MATSUI, Kazumi KASAJIMA, Masazumi HADA, Tomomi NAGATA, Nobuko SENGA, Yumiko YASUI, Nobuyuki FUKUISHI and Masaaki AKAGI J. Toxicol. Sci.,2005; 30:103-110 |
| Paper： | PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS |
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| Author： |
Toshinori YAMAMOTO, Tamio FUKUSHIMA, Rie KIKKAWA, Hiroshi YAMADA and Ikuo HORII J. Toxicol. Sci.,2005; 30:111-126 |
11th 2005
| Paper： | AUTOMATED MEASUREMENT OF FREEZING TIME TO CONTEXTUAL AND AUDITORY CUES IN FEAR CONDITIONING AS A SIMPLE SCREENING METHOD TO ASSESS LEARNING AND MEMORY ABILITIES IN RATS. |
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| Author： |
Hiroaki TAKAHASHI J. Toxicol. Sci., 2004; 29:53-61 |
| Paper： | SUBCELLULAR DISTRIBUTION OF DI-(2-ETHYLHEXYL) PHTHALATE IN RAT TESTIS. |
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| Author： |
Hiroshi ONO, Yoshiaki SAITO, Kiyoshi IMAI and Masanobu KATO J. Toxicol. Sci., 2004; 29:113-124 |
10th 2004
| Paper： | BIOCHEMICAL AND MICROARRAY ANALYSES OF BUPIVACAINE-INDUCED APOPTOSIS. |
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| Author： |
Akira UNAMI, Yasuo SHINOHARA, Tomokazu ICHIKAWA and Yoshinobu BABA J. Toxicol. Sci., 2003; 28:77-94 |
| Paper： | DIFFERENTIAL MODULATION OF MUSCARINIC RECEPTORS IN THE RAT BRAIN BY REPEATED EXPOSURE TO METHYL PARATHION. |
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| Author： |
SUN Tingting, MA Tangeng, HO Ing K. J. Toxicol. Sci., 2003; 28:427-438 |
9th 2003
| Paper： | ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE- AND ETHINYLESTRADIOL-TREATED RATS. |
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| Author： |
Chiaki KATOH, Satoshi KITAJIMA, Yumiko SAGA, Jun KANNO, Ikuo HORII and Tohru INOUE J. Toxicol. Sci., 2002; 27:87-96 |
| Paper： | COMBINATION OF FIXATION USING PLP FIXATIVE AND EMBEDDING IN PARAFFIN BY THE AMeX METHOD IS USEFUL FOR HISTOCHEMICAL STUDIES IN ASSESSMENT OF IMMUNOTOXICITY. |
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| Author： |
Masami SUZUKI, Kiyoka KATSUYAMA, Kenji ADACHI, Yumie OGAWA, Keigo YOROZU, Eteuko FUJII, Yasuyuki MISAWA and Tetsuro SUGIMOTO J. Toxicol. Sci., 2002; 27:165-172 |
| Paper： | IN VITRO CYTOTOXICITY ASSAY TO SCREEN COMPOUNDS FOR APOPTOSIS-INDUCING POTENTIAL ON LYMPHOCYTES AND NEUTROPHILS. |
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| Author： |
Kazuyuki NAGAMI, Yasunaga KAWASHIMA, Hiroshi KUNO, Masayuki KEMI and Hiroyoshi MATSUMOTO J. Toxicol. Sci., 2002; 27:191-203 |
| Paper： | LOCAL LYMPH NODE ASSAY WITH NON-RADIOISOTOPE ALTERNATIVE ENDPOINTS. |
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| Author： |
Akiko SUDA, Masahiro YAMASHITA, Mitsuyuki TABEI, Kazuhiko TAGUCHI, Hans-Werner Vohr, Naohisa TSUTSUI, Ritsuyoshi SUZUKI, Katsuaki KIKUCHI, Keisuke SAKAGUCHI, Kouki MOCHIZUKI and Kazuichi NAKAMURA J. Toxicol. Sci., 2002; 27:205-218 |
8th 2002
| Paper： | DOSE-THRESHOLD FOR THYROID TUMOR-PROMOTING EFFECTS OF ORALLYADMINISTERED KOJIC ACID IN RATS AFTER INITIATION WITH N-bis(2-HYDROXYPROPYL) NITROSAMINE. |
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| Author： |
Toru TAMURA, Kunitoshi MITSUMORI, Horoshi ONODERA, Nariaki FUJIMOTO, Kazuo YASUHARA, Kiyoshi TAKEGAWA, Hisayoshi TAKAGI and Masao HIROSE J. Toxicol. Sci., 2001; 26:85-94 |
| Paper： | JUSTIFICATION OF MEASUREMENT OF EIGHT CONGENERS LEVELS INSTEAD OF TWENTY CONGENERS OF DIOXINSZ FOR MASS SCREENING OF HUMAN EXPOSURE. |
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| Author： |
Kimiyoshi KITAMURA, Kazuyuki YOSHIKAWA, Masahiko IWAMA and Minako NAGAO J. Toxicol. Sci., 2001; 26:163-168 |
| Paper： | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORα (PPARα) AGONIST, WY14,643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES. |
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| Author： |
Takako HAMANO, Kiyoshi KOBAYASHI, Tetsuya SAKAIRI, Masao HAYASHI and Mamoru MUTAI J. Toxicol. Sci., 2001; 26:275-284 |
| Paper： | COLLABORATIVE STUDY ON RAT SPERM MOTION ANALYSIS USING CELLSOFT SERIES 4000 SEMEN ANALYZER. |
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| Author： |
Yoshiki BAN, Masato NAYA, Tatsuya NISHIMURA, Masako KANETO, Kurajiro KISHI, Tadahiro INOUE, Hiroshi YOSHIZAKI and Yojiro OOSHIMA J. Toxicol. Sci., 2001; 26:9-24 |
| Paper： | OVERVIEW OF STUDIES ON RAT SPERM MOTION ANALYSIS USING A HAMILTON-THORME SPERM ANALYZER.--COLLABORATIVE WORKING STUDY--. |
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| Author： |
Masashi KATO, Katsuhiro FUKUNISHI, Sunao IKEGAWA, Hashihiro HIGUCHI, Masako SATO, Masao HOROMOTO and Shin ITO J. Toxicol. Sci., 2001; 26:285-297 |
7th 2001
| Paper： | Sex-related effect of hemin on cytochrome P450 and drug-metabolizing enzymes in rat liver. |
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| Author： |
Yasuna KOBAYASHI, Naomi OHSHIRO, Michiya SUZUKI, Tadanori SASAKI, Shogo TOKUYAMA, Takemi YOSHIDA and Toshinori YAMAMOTO J. Toxicol. Sci., 2000; 25:213-222 |
| Paper： | Elevation of steroid 5α-reductase mRNA levels in rat cerebellum by toluene inhalation : Possible relation to GFAP expression. |
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| Author： |
Takako GOTOHDA, Aki KUWADA, Kyoji MORITA, Shin-ichi KUBO and Itsuo TOKUNAGA J. Toxicol. Sci., 2000; 25:223-231 |
6th 2000
| Paper： | Characterization of epididymal sperm motion and its correlation with stages of target cells in rats given α-chlorohydrin, cyclophosphamide or nitrazepam. |
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| Author： |
Masako KANETO, Susumu KANAMORI, Katsumi HARA and Kurajiro KISHI J. Toxicol. Sci., 1999; 24:187-197 |
| Paper： | Induction of unscheduled DNA synthesis in hairless mouse epidermis by skin carcinogens. |
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| Author： |
Masaaki MORI, Hiroshi KOBAYASHI, Chiyomi SUGIYAMA, Yoshiko KATSUMURA and Chie FURIHATA J. Toxicol. Sci., 1999; 24:217-226 |
5th 1999
| Paper： | Induction of leyding cell tumors by lacidipine via up-regulation of the LHRH receptor on leyding cells in rats. |
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| Author： |
Yoshimasa HAMADA and Yoshihiro FUTAMURA J. Toxicol. Sci., 1998; 23:35-52 |
| Paper： | Methylmercuty-induced microtubule depolymerization leads to inhibition of tubulin synthesis. |
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| Author： |
Kyoko MIURA, Yuka KOBAYASHI, Haruka TOYODA and Nobumasa IMURA J. Toxicol. Sci., 1998; 23:379-388 |
4th 1998
| Paper： | Effect of hyperprolactinemia induced by neuroleptic agent,timiperone, on porphyrin content of mouse Harderian gland. |
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| Author： |
Tetsuyo KAJIMURA, Hiroshi SATOH and Mamoru NOMURA J. Toxicol. Sci., 1997; 22:219-229 |
| Paper： | A flow cytometric analysis of cytotoxic effects of nitrobenzene on rat spermatogenesis. |
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| Author： |
Shigeru IIDA, Hirofumi MISAKA and Masato NAYA J. Toxicol. Sci., 1997; 22:397-407 |
3rd 1997
| Paper： | Auditory brainstem response(ABR) and effects of furosemide on ABR in conscious F344 rats. |
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| Author： |
Harushige OZAKI, Kazuyuki KURATA, Akira HORINOUCHI and Takao ANDO J. Toxicol. Sci., 1996; 21:167-175 |
2nd 1996
| Paper： | Effects of all-trans-retinoic acid on limb development in the genetic polydactyly mouse. |
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| Author： |
Minoru TAMAGAWA, Jiro MORITA and Ichiro NARUSE J. Toxicol. Sci., 1995; 20:383-393 |
| Paper： | Effects of medroxyprogesterone acetate and β-estradiol on interleukin-6 production from osteoblasts and bone marrow macrophages of Wistar rats of different ages. |
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| Author： |
Yoshihiro FUTAMURA J. Toxicol. Sci., 1995; 20:155-160 |
1st 1995
| Paper： | Occurrence of autoantibody to protein disulfide isomerase in rats with xenobiotic-induced hepatitis. |
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| Author： |
Sekio NAGAYAMA, Tsuyoshi YOKOI, Yasuro KAWAGUCHI and Tetsuya KAMATAKI J. Toxicol. Sci., 1994; 19:155-161 |
| Paper： | Tacrolimus(FK506)-induced nephrotoxicity in spontaneous hypertensive rats. |
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| Author： |
Takashi MITAMURA, Atsushi YAMADA, Hisao ISHIDA, Shiro FUJIHIRA, Kaname OHARA, Hideyo NOGUCHI and Yasuhiro MINE J. Toxicol. Sci., 1994; 19:219-226 |