Awards / Pfizer Award
Winners
2024
| Title: | A rapid screening assay for L452R and T478K spike mutations in SARS-CoV-2 Delta variant using high-resolution melting analysis |
| Author: | Akira Aoki, Hirokazu Adachi, Yoko Mori, Miyabi Ito, Katsuhiko Sato, Kenji Okuda, Toru Sakakibara, Yoshinori Okamoto, Hideto Jinno J. Toxicol. Sci., Vol. 46, No. 10, 471-476, 2021 |
| Title: | Environmental cadmium exposure induces kidney tubular and glomerular dysfunction in the Myanmar adults |
| Author: | Muyar Win-Thu, Ohnmar Myint-Thein, Tin-Tin Win-Shwe, Ohn Mar J. Toxicol. Sci., Vol. 46, No. 7, 319-328, 2021 |
| Title: | Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota |
| Author: | Natsumi Seki, Masahiro Akiyama, Hiroto Yamakawa, Koji Hase, Yoshito Kumagai, Yun-Gi Kim J. Toxicol. Sci., Vol. 46, No. 2, 91-97, 2021 |
| Title: | Chronic cardiotoxicity assessment of BMS-986094, a guanosine nucleotide analogue, using human iPS cell-derived cardiomyocytes |
| Author: | Shota Yanagida, Ayano Satsuka, Sayo Hayashi, Atsushi Ono, Yasunari Kanda J. Toxicol. Sci., Vol. 46, No. 8, 359-369, 2021 |
2023
| Title: | Involvement of metal transporters in the intestinal uptake of cadmium |
| Author: | Hisayoshi Ohta, Kenichi Ohba J. Toxicol. Sci. Vol.45, No.9, 539-548, 2020 |
| Title: | A novel screening test to predict the developmental toxicity of drugs using human induced pluripotent stem cells |
| Author: | Nobuo Aikawa J. Toxicol. Sci. Vol.45, No.4, 187-199, 2020 |
| Title: | Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation |
| Author: | Masayo Hirao-Suzuki, Shuso Takeda, Takayuki Koga, Masufumi Takiguchi, Akihisa Toda J. Toxicol. Sci. Vol.45, No.4, 227-236, 2020 |
2022
| Title: | Comparison of the developmental/reproductive toxicity and hepatotoxicity of phthalate esters in rats using an open toxicity data source |
| Author: | Kaori Ambe, Yuko Sakakibara, Aya Sakabe, Hayato Makino, Tatsuya Ochibe, Masahiro Tohkin J. Toxicol. Sci. Vol.44, No.4, 245-255, 2019 |
| Title: | Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells |
| Author: | Takato Hara, Shihoko Nakano, Yuki Kitamura, Chika Yamamoto, Shuji Yasuike, Toshiyuki Kaji J. Toxicol. Sci. Vol.44, No.12, 845-848, 2019 |
| Title: | Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells |
| Author: | Tomoya Fujie, Fukuta Takenaka, Eiko Yoshida, Shuji Yasuike, Yasuyuki Fujiwara, Yasuhiro Shinkai, Yoshito Kumagai, Chika Yamamoto, Toshiyuki Kaji J. Toxicol. Sci. Vol.44, No.5, 327-333, 2019 |
| Title: | Segment-specific and direction-dependent transport of cadmium and manganese in immortalized S1, S2, and S3 cells derived from mouse kidney proximal tubules |
| Author: | Hitomi Fujishiro, Satoko Hamao, Misaki Isawa, Seiichiro Himeno J. Toxicol. Sci. Vol.44, No.9, 611-619, 2019 |
2021
| Title: | A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers |
| Author: | Ryuji Watari, Motoharu Kakiki, Ayumi Oshikata, Toshiaki Takezawa, Chihiro Yamasaki, Yuji Ishida, Chise Tateno, Yukie Kuroda, Seiichi Ishida, Kazutomi Kusano J. Toxicol. Sci. Vol.43, No.8, 521-529, 2018 |
| Title: | Comparative study for carcinogenicity of 7 different multi-wall carbon nanotubes with different physicochemical characteristics by a single intraperitoneal injection in male Fischer 344 rats |
| Author: | Yoshimitsu Sakamoto, Motoki Hojo, Yuki Kosugi, Kimiyo Watanabe, Akihiko Hirose, Akiko Inomata, Toshinari Suzuki, Dai Nakae J. Toxicol. Sci. Vol.43, No.10, 587-600, 2018 |
| Title: | Bisphenol AF as an activator of human estrogen receptor β1 (ER β1) in breast cancer cell lines |
| Author: | Hiroyuki Okazaki, Masayo Hirao-Suzuki, Shuso Takeda, Yukimi Takemoto, Ramu Mizunoe, Koichi Haraguchi, Kazuhito Watanabe, Masufumi Takiguchi, Hironori Aramaki
J. Toxicol. Sci. Vol.43, No.5, 321-327, 2018 |
| Title: | Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat |
| Author: | Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Kousei Ito
J. Toxicol. Sci. Vol.43, No.5, 339-351, 2018 |
| Title: | Photodynamic therapy using talaporfin sodium induces heme oxygenase-1 expression in rat malignant meningioma KMY-J cells |
| Author: | Tsutomu Takahashi, Saki Suzuki, Suzuka Misawa, Jiro Akimoto, Yo Shinoda, Yasuyuki Fujiwara
J. Toxicol. Sci. Vol.43, No.5, 353-358, 2018 |
| Title: | Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism |
| Author: | Tin-Tin Win-Shwe, Nay Chi Nway, Motoki Imai, Thet-Thet Lwin, Ohn Mar, Hidehiro Watanabe
J. Toxicol. Sci. Vol.43, No.11, 631-643, 2018 |
2020
| Title: | Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells |
| Author: | Naoya Hirata, Shigeru Yamada, Yuko Sekino, Yasunari Kanda J. Toxicol. Sci. Vol.42, No.2, 193-204, 2017 |
| Title: | Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance |
| Author: | Hiroko Izumi-Nakaseko, Yuji Nakamura, Takeshi Wada, Kentaro Ando, Yasunari Kanda, Yuko Sekino, Atsushi Sugiyama J. Toxicol. Sci. Vol.42, No.2, 183-192, 2017 |
| Title: | Chronotoxicity of bromobenzene-induced hepatic injury in mice |
| Author: | Hiroki Yoshioka, Tsunemasa Nonogaki, Nobuyuki Fukuishi, Yasuro Shinohara,
Gi-Wook Hwang, Katsumi Ohtani, Nobuhiko Miura
J. Toxicol. Sci. Vol.42, No.2, 251-258, 2017 |
2019
| Title: | Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells |
| Author: | Yang Zeng, Yoshika Kurokawa, Tin-Tin Win-Shwe, Qin Zeng, Seishiro Hirano, Zhenya Zhang, Hideko Sone J. Toxicol. Sci. Vol.41, No.3, 351-370, 2016 |
| Title: | Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate |
| Author: | Hiroki Yoshioka, Haruki Usuda, Tsunemasa Nonogaki, Satomi Onosaka J. Toxicol. Sci. Vol.41, No.1, 55-63, 2016 |
| Title: | Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression |
| Author: | Kanae Umeda, Yaichiro Kotake, Masatsugu Miyara, Keishi Ishida, Seigo Sanoh, Shigeru Ohta J. Toxicol. Sci. Vol.41, No.2, 255-264, 2016 |
| Title: | NF-κB activation via MyD88-dependent Toll-like receptor signaling is inhibited by trichothecene mycotoxin deoxynivalenol |
| Author: | Kei-ichi Sugiyama, Masashi Muroi, Mawo Kinoshita, Osamu Hamada, Yuji Minai, Yoshiko Sugita-Konishi, Yoichi Kamata, Ken-ichi Tanamoto J. Toxicol. Sci. Vol.41, No.2, 273-279, 2016 |
2018
| Title: | The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules |
| Author: | Kumiko Kohri, Eiko Yoshida, Shuji Yasuike, Tomoya Fujie, Chika Yamamoto, Toshiyuki Kaji J. Toxicol. Sci. Vol.40, No.3, 321-327, 2015 |
| Title: | In silico risk assessment for skin sensitization using artificial neural network analysis |
| Author: | Kyoko Tsujita-Inoue, Tomomi Atobe, Morihiko Hirota, Takao Ashikaga, Hirokazu Kouzuki J. Toxicol. Sci. Vol.40, No.2, 193-209, 2015 |
| Title: | Chromium (VI)-induced transformation is enhanced by Zn deficiency in BALB/c 3T3 cells |
| Author: | Tomoki Kimura, Akira Onodera, Fumika Okumura, Tsuyoshi Nakanishi, Norio Itoh J. Toxicol. Sci. Vol.40, No.3, 383-387, 2015 |
| Title: | Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST): A novel rapid and highly reproducible in vitro test for embryotoxicity by measuring cytotoxicity and differentiation toxicity using engineered mouse ES cells |
| Author: | Florian Le Coz, Noriyuki Suzuki, Hirohisa Nagahori, Takashi Omori, Koichi Saito J. Toxicol. Sci. Vol.40, No.2, 251-261, 2015 |
2017
| Title: | New recreational drug 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (alpha-PVP) activates central nervous system via dopaminergic neuron |
| Author: | Asuka Kaizaki, Sachiko Tanaka and Satoshi Numazawa J. Toxicol. Sci. Vol.39, No.1, 1-6, 2014 |
| Title: | Involvement of epithelial-mesenchymal transition in methotrexate-induced pulmonary fibrosis |
| Author: | Masayuki Ohbayashi, Satoshi Kubota, Aya Kawase, Noriko Kohyama, Yasuna Kobayashi and Toshinori Yamamoto J. Toxicol. Sci. Vol.39, No.2, 319-330, 2014 |
| Title: | Effect of talaporfin sodium-mediated photodynamic therapy on cell death modalities in human glioblastoma T98G cells |
| Author: | Yuichi Miki, Jiro Akimoto, Michika Hiranuma and Yasuyuki Fujiwara J. Toxicol. Sci. Vol.39, No.6, 821-827, 2014 |
| Title: | FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation |
| Author: | Ke Du, Tsutomu Takahashi, Shusuke Kuge, Akira Naganuma and Gi-Wook Hwang J. Toxicol. Sci. Vol.39, No.6, 861-866, 2014 |
| Title: | Early indicators of delayed adverse effects in female reproductive organs in rats receiving neonatal exposure to 17alpha-ethynylestradiol |
| Author: | Miwa Takahashi, Kaoru Inoue, Tomomi Morikawa, Saori Matsuo, Seigo Hayashi, Kei Tamura, Gen Watanabe, Kazuyoshi Taya and Midori Yoshida J. Toxicol. Sci. Vol.39, No.5, 775-784, 2014 |
2016
| Title: | Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression |
| Author: | Daisuke Hibi, Aki Kijima, Ken Kuroda, Yuta Suzuki, Yuji Ishii, Meilan Jin, Masahiro Nakajima, Yoshiko Sugita-Konishi, Tokuma Yanai, Takehiko Nohmi, Akiyoshi Nishikawa, Takashi Umemura J. Toxicol. Sci. Vol.38, No.1, 57-69, 2013 |
| Title: | Postnatal exposure to low-dose bisphenol A influences various emotional conditions |
| Author: | Tetsuya Fujimoto, Kazuhiko Kubo, Yasuo Nishikawa, Shuji Aou J. Toxicol. Sci. Vol.38, No.4, 539-546, 2013 |
| Title: | Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin |
| Author: | Kiyonori Kai, Takashi Yamaguchi, Yu Yoshimatsu, Junzo Kinoshita, Munehiro Teranishi, Wataru Takasaki J. Toxicol. Sci. Vol.38, No.2, 269-277, 2013 |
| Title: | Genotoxicity and reactive oxygen species production induced by magnetite nanoparticles in mammalian cells |
| Author: | Masanobu Kawanishi, Sayaka Ogo, Miho Ikemoto, Yukari Totsuka, Kousuke Ishino, Keiji Wakabayashi, Takashi Yagi J. Toxicol. Sci. Vol.38, No.3, 503-511, 2013 |
2015
| Title: | Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans |
| Author: |
Kozue Yaginuma-Sakurai, Katsuyuki Murata, Miyuki Iwai-Shimada, Kunihiko Nakai, Naoyuki Kurokawa, Nozomi Tatsuta and Hiroshi Satoh J. Toxicol. Sci. Vol.37, No.1, 123-130, 2012 |
| Title: | Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice |
| Author: |
Atsumi Yamaguchi, Tomoko Fujitani, Ken-ichi Ohyama, Dai Nakae, Akihiko Hirose, Tetsuji Nishimura and Akio Ogata J. Toxicol. Sci. Vol.37, No.1, 177-189, 2012 |
| Title: | Methylglyoxal activates the human transient receptor potential ankyrin 1 channel |
| Author: |
Susumu Ohkawara, Toshiko Tanaka-Kagawa, Yoko Furukawa and Hideto Jinno J. Toxicol. Sci. Vol.37, No.4, 831-835, 2012 |
2014
| Title: | Protein disulfide isomerase knockdown-induced cell death is cell-line-dependent and involves apoptosis in MCF-7 cells |
| Author: |
Tomoyo Hashida, Yaichiro Kotake, Shigeru Ohta J. Toxicol. Sci. Vol.36, No.1, 1-7, 2011 |
| Title: | Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo |
| Author: |
Maki Tokumoto, Yasuyuki Fujiwara, Akinori Shimada, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Masahiko Satoh J. Toxicol. Sci. Vol.36, No.2, 191-200, 2011 |
| Title: | Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury |
| Author: |
Gi-Wook Hwang, Jin-Yong Lee, Katsunori Ryoke, Fujio Matsuyama, Jong-Mu Kim, Tsutomu Takahashi, Akira Naganuma J. Toxicol. Sci. Vol.36, No.3, 389-391, 2011 |
2013
| Title: | Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro |
| Author: |
Mika Senzui, Toshiaki Tamura, Keiko Miura, Yoshiaki Ikarashi,Yoshiteru Watanabe and Makiko Fujii J. Toxicol. Sci., Vol. 35, No. 1, 107-113, 2010 |
| Title: | Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice |
| Author: |
Yuta Takahashi, Keisuke Mizuo, Yusuke Shinkai, Shigeru Oshio and Ken Takeda J. Toxicol. Sci., Vol. 35, No. 5, 749-756, 2010 |
| Title: | Immunochemical method to detect proteins that undergo selective modification by 1,2-naphthoquinone derived from naphthalene through metabolic activation |
| Author: |
Takashi Miura and Yoshito Kumagai J. Toxicol. Sci., Vol. 35, No. 6, 843-852, 2010 |
2012
| Title: | Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats |
| Author: |
Yoshimitsu Sakamoto, Dai Nakae, Kuniaki Tayama, Akihiko Maekawa, Kiyoshi Imai, Akihiko Hirose, Tetsuji Nishimura and Akio Ogata J. Toxicol. Sci., Vol. 34, No. 1, PP.65-76 (2009) |
| Title: | Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist |
| Author: |
Katsunori Yamaura, Eriko Suwa, Hiromi Sato and Koichi Ueno J. Toxicol. Sci., Vol. 34, No. 4, PP.427-431 (2009) |
| Title: | Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes) |
| Author: |
Joon-Woo Kim, Hiroshi Ishibashi, Yuji Takao, Masashi Hirano, Minoru Koga and Koji Arizono J. Toxicol. Sci., Vol. 34, No. 2, PP.227-232 (2009) |