Awards / Outstanding Technology Award
Winners
2025
| Title: | Development of a method for predicting drug-induced convulsions using machine learning and heart rate variability analysis |
| Winner: | KUGA Kazuhiro |
| Affiliation: | Astellas Pharma Inc. |
| Title: | Development of an in vitro evaluation system for pseudo-allergic reaction using canine and human MRGPRX2-expressing cells |
| Winner: | HAMAMURA-YASUNO Eri |
| Affiliation: | Daiichi Sankyo Co., Ltd. |
| Title: | Optimization and validation of the zebrafish embryo MEFL test method for assessing embryo-fetal developmental toxicity |
| Winner: | MORI Kanako |
| Affiliation: | Astellas Pharma Inc. |
2024
| Title: | Construction of an in vitro-based bile canaliculi model with improved reproducibility |
| Winner: | KITAGUCHI Takashi |
| Affiliation: | Global Food Safety Institute, Nissin Foods Holdings Co., Ltd. |
| Title: | Establishing the versatility of miR-216a and miR-217 as biomarkers of acute pancreatic toxicity |
| Winner: | KURASHIGE Seiichiro |
| Affiliation: | EA Pharma Co., Ltd. (Current: Kyowa Kirin Co., Ltd.) |
| Title: | Efforts to improve extrapolation of in vitro hepatotoxicity assessment systems |
| Winner: | TAKEMURA Akinori |
| Affiliation: | Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University |
2023
| Title: | Validation of prediction method of addiction-inducing drug based on electrical activity of cultured human iPS cell-derived dopamine neurons |
| Winner: | ISHIBASHI Yuto |
| Affiliation: | Graduate School of Engineering, Tohoku Institute of Technology |
| Title: | Reactive oxygen species (ROS) assay without using DMSO |
| Winner: | OHTAKE Toshiyuki |
| Affiliation: | Shiseido Co., Ltd. |
| Title: | Understanding the drug-induced hepatotoxicity in rats —Involvement of the CYP1A1 inhibition-mediated activation of the aryl hydrocarbon receptor (AHR)— |
| Winner: | YODA Tomomi |
| Affiliation: | Preclinical Research Unit, Sumitomo Pharma Co., Ltd. |
2022
| Title: | Development of cell-based high-throughput screening for the evaluation of reactive metabolite formation potential |
| Winner: | HARADA Kosuke |
| Affiliation: | Drug Safety Research & Evaluation, Takeda Pharmaceutical Company Limited |
| Title: | Detection of acute and chronic cardiotoxicity by imaging-based contractile assay system using human iPS cell-derived cardiomyocytes |
| Winner: | YANAGIDA Shota |
| Affiliation: | Division of Pharmacology, National Institute of Health Sciences / Graduated School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University |
2021
| Title: | Approaches to understanding idiosyncratic drug toxicity using human HLA transgenic mice |
| Winner: | AOKI Shigeki |
| Affiliation: | Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University |
| Title: | Establishment of a new risk assessment method for skin sensitization by applying the dermal sensitization threshold |
| Winner: | NISHIJO Taku |
| Affiliation: | Safety Science Research Laboratories, Kao Corporation |
2020
| Title: | Human iPS cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells |
| Winner: | IKUNO Tatsuya |
| Affiliation: | Research Division, Chugai Pharmaceutical Co., Ltd. |
| Title: | Establishment of human iPS cell-derived hepatocyte panel that defects drug metabolizing enzymes, CYPs, using genome editing technologies for drug toxicity screening |
| Winner: | DEGUCHI Sayaka |
| Affiliation: | Graduate School of Pharmaceutical Sciences, Osaka University |
| Title: | Development of a novel in chemico method for skin sensitization, the amino acid derivative reactivity assay (ADRA) |
| Winner: | YAMAMOTO Yusuke |
| Affiliation: | Safety Evaluation Center, Ecology & Quality Management Div., ESG Div., FUJIFILM Corporation |
2019
| Title: | Application of motion field imaging of human iPS cell-derived cardiomyocytes to cardiac safety assessment |
| Winner: | ISOBE Takehito |
| Affiliation: | Research Division, Chugai Pharmaceutical Co., Ltd. |
| Title: | Chimeric mice with humanized livers demonstrate human-specific hepatotoxicity caused by a therapeutic antibody against TRAIL-receptor 2/death receptor 5 |
| Winner: | NIHIRA Kaito |
| Affiliation: | Kyowa Hakko Kirin Co., Ltd. |
| Title: | A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers |
| Winner: | WATARI Ryuji |
| Affiliation: | Drug Metabolism and Pharmacokinetics Tsukuba, Global Drug Metabolism and Pharmacokinetics, Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., Department of Genomics-Based Drug Discovery, Graduate School of Comprehensive Human Sciences, University of Tsukuba |
2018
| Title: | Establishment of an novel 3D culture method, air-liquid interface organoid culture and application in toxicity test |
| Winner: | USUI Tatsuya |
| Affiliation: | Tokyo University of Agriculture and Technology |
| Title: | A rapid mitochondrial toxicity assay utilizing rapidly changing cell energy metabolism |
| Winner: | SANUKI Yosuke |
| Affiliation: | Asahi Kasei Pharma Co. |
2017
| Title: | Proposal of a universal in vitro assay for detection of potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals |
| Winner: | IWATA Yoshika |
| Affiliation: | Safety Assessment Dept., Chugai Pharmaceutical Co., Ltd. |
| Title: | Risk assessment of drug-induced liver injury by the expression of immune and inflammation-related factors and microRNAs |
| Winner: | ODA Shingo |
| Affiliation: | Nagoya University Graduate School of Medicine |
| Title: | Establishment of short/medium-term carcinogenesis bioassay by dermal application |
| Winner: | NUMANO Takamasa |
| Affiliation: | DIMS Institute of Medical Science, Inc. |